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Pharmacology Anti Thyroid e9e45624

Conversion of T4 to T3 is inhibited by all except:

A
Propranolol
B
Propylthiouracil
C
Amiodarone
D
Methimazole
High-Yield Explanation
Ans. (D) Methimazole(Ref: KDT 8/e p252-253)Methimazole inhibits only thyroid peroxidase whereas propylthiouracil inhibits thyroid peroxidase as well as 5'-deiodinase. Later is involved in peripheral conversion of T4 to T3 (Katzung 12/e p688, Goodman Gilman 12/e p1150)

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