False +ve VDRL is seen in:

Ans. (b) i.e. Infectious mononucleosis Causes of False -positive VDRL Acute falss-posltlve roaction <6 monthg Chronlc false-posltlve reactlon > 6 month Recent viral illness or immunization - Aging Genital herpes - Autoimmune disorders HIV infection - SLE Malaria -Rheumatoid ahritis Parenteral drug used - Parenteral drugused Other lnfective endocarditis - Hepatitis infection Pregnancy - Infectious mononucleosis Infectious mononucleosis is acute infection of EBV and can give false (+)ve VDRL In CMDT '08, p 1269 Leprosy is also mentioned as cause of false (+)ve VDRL: but with use of newer non-lipoidal VDRL test, leprosy no longer give false positive result. False negative VDRL. Seen when very high antibody titre is present . Note: VDRL measures IgM and IgG directed against cardiolipin-lecithin-cholesterol antigen complex