An elderly patient is receiving a blood transfusion for anemia due to myelodysplastic syndrome (MDS). He was diagnosed with MDS 2 years ago and over the past 6 months has required blood transfusions every 6 weeks for symptomatic anemia. His past medical history also includes hypertension, Type 2 diabetes, and coronary artery disease. Halfway through the transfusion of the second unit of packed red blood cells he develops tachypnea, lumbar pain, tachycardia, and nausea. Which of the following is the most likely explanation?