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Pathology Inflammation & Repair e95edb14

The following statements are true regarding neutrophil extracellular trap

A
Produced by neutrophils in response to infectious pathogens and inflammatory mediators
B
Provide a high concentration of antimicrobial substances at sites of infection
C
Prevent the spread of the microbes by trapping them in the fibrils
D
All the above
High-Yield Explanation
Ans. (d) All the above(Ref: Robbins 9th/pg 81)Neutrophil extracellular traps (NETs) are extracellular fibrillar networks that provide a high concentration of antimicrobial substances at sites of infection and prevent the spread of the microbes by trapping them in the fibrils. They consist of a viscous meshwork of nuclear chromatin that binds and concentrates granule proteins such as antimicrobial peptides and enzymes

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