In chronic alcoholics which the following enzymes are inhibited-

Ans. is 'a' i.e., Glycogen phosphorylase kinase Alcohol effects on Carbohyrate metabolism* Ethanol adversely affects the carbohydrate metabolism in skeletal muscle.* Chronic alcohol intake is associated with an increase in glycogen concentration in skeletal muscles because of incapacity to degrade glycogen due to partial inhibition of glycogen phosphorylase kinase at glycogenolysis and by decrease in pyruvate kinase activity at glycolysis.* Activities of the glycolytic enzymes phosphofructokinase and lactate dehydrogenase are not affected.