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Gynaecology & Obstetrics Malformation of the Female Generative Organs e82acaba

All of the following take part in male genital tract development except

A
SRY
B
SOX-9
C
FGF-9
D
WNT-4
High-Yield Explanation
Ans. is d, i.e. WNT-4Ref: Langman Embryology 12th/ed, p46-247Genes for male developmentSRY geneMaster Gene for testis developmentSOX 9SRY and SOX 9 induce testis to form FGF-9 (chemotactic factor). FGF-9 causes tubules from mesonepric duct to penetrate gonadal ridgeSF1 (steroidogenic factor)It stimulates differentiation of sertoli or leydig cellsWNT-4 is ovary determining gene. This gene upregulates DAXI which inhibits the function of SOX 9 in females.

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