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Pathology General pathology e77a5910

S100 is a marker used in the diagnosis of all Except

A
Melanoma
B
Schwannoma
C
Histiocytoma
D
Basal cell cancer
High-Yield Explanation
Acidic protein, 100% Soluble in ammonium sulfate at neutral pH (derivation of name) S100 protein family is multigenic group of nonubiquitous cytoplasmic EF-hand Ca2+-binding proteins, sharing significant structural similarities at both genomic and protein levels; S100 protein family has 24 known human members each coded by a separate gene; at least 19 on chromosome 1q21 Helps regulate cell contraction, motility, growth, differentiation, cell cycle progression, transcription and secretion Structurally similar to calmodulin

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