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Medicine General e70429c6

Most chemoresistani tumors among the following is:

A
Synol sarcoma
B
Osteosarcoma
C
Malignant fibrous histiocytoma
D
Embryonal rhabdomyosarcoma
High-Yield Explanation
Malignant fibrous histiocytoma Repeat Nov 2006 Of the given options Malignant fibrous histiocytoma appears to be most chemoresistant. Chemotherapy forms a pa of t/t of all the other three options, whereas only surgery & radiotherapy are the t/t options for malignant fibrous histiocytoma (see the above references) Chemosensitivity of different tumors 1.Highly sensitive (which may be used by chemotherapy) Teratoma of testes Hodgkin's disease High grade non-Hodgkin lymphoma Wilm's tumour Embryonal rhabdomyosarcoma Chorio-carcinoma Acute lymphoblastic leukaemia in children Ewing's sarcoma 2.Moderately sensitive (in which chemotherapy may contribute to cure) Small cell carcinoma Breast carcinoma Low grade non-Hodgkin lymphoma Acute myeloid leukaemia Ovarian cancer Myeloma 3. Relatively insensitive (in which chemotherapy may sometimes produce palliation) Gastric carcinoma Bladder carcinoma Squamous carcinoma of head and neck Soft tissue sarcoma

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