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Medicine General e688aca8

Richter's syndrome refers to which of the following malignant transformation?

A
CLL evolving into aggressive lymphoma
B
Hairy cell leukemia evolving to AML
C
Blast crisis in CML
D
Splenic infiltration in NHL
High-Yield Explanation
Richter's transformation or Richter's syndrome is a complication of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia (HCL) in which the leukemia changes into a fast-growing diffuse large B cell lymphoma.

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