Characteristic pathological finding in carcinoid of hea-

The carcinoid syndrome results from bioactive compounds such as serotonin released by carcinoid tumors (; systemic manifestations include flushing, diarrhea, dermatitis, and bronchoconstriction. Carcinoid hea disease refers to the cardiac manifestation caused by the bioactive systemic syndrome develops. Cardiac lesions typically do not occur until there is a massive hepatic metastatic burden, since the liver normally catabolizes circulating mediators before they can affect the hea. Classically, endocardium and valves of the right hea are primarily affected since they are the first cardiac tissues bathed by the mediators released by gastrointestinal carcinoid tumors. (Robbins basic pathology,9th edition,pg no.395)