All of the following are indications for eicosanoids or their inhibitors EXCEPT:

PGE1 derivatives like misoprostol are used for aboion. PG inhibitors like indomethacin and ibuprofen are used for treatment of PDA. PGE1 derivative alprostadil is used to keep the ductus aeriosus open before surgery of patient with transposition of great vessels. PG like iloprost are indicated in pulmonary hypeension but not in essential systemic hypeension.