Buerger’s Disease is

BUERGER'S DISEASE (THROMBOANGITIS OBLITERANS) → Segmental inflammatory disease, affecting small and medium sized arteries in upper and lower extremities. → Inflammatory process involves neighboring veins and nerves. → Definite relationship with smoking. Histopathology → Sharply segmental acute and chronic vasculitis of small and medium vessels with thrombosis of lumen, which may undergo organization and recanalization. → Thrombus contains microabsecess Inflammatory process extends to involve neighboring veins and nerves. With time, all three structures (artery, vein and nerve) become incased in fibrous tissue. Clinical Features (RIM) → Characterized by triad of intermittent claudication, Raynaud's phenomenon and migratory superficial vein thrombophlebitis. Typically seen in young (<40 years), male smokers.