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Biochemistry General e625b25d

Which of the following enzymes found in the liver is involved in gluconeogenesis during the postabsorptive state?

A
Glucose-6-phosphate dehydrogenase
B
6-phosphogluconate dehydrogenase
C
Glucose-6-phosphatase
D
Glucokinase
High-Yield Explanation
Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase are irreversible enzymes in the pentose phosphate pathway. Glucokinase is involved with phosphorylation of glucose when hepatic concentrations of glucose are high. Glucose-6-phosphatase hydrolyzes glucose-6-phosphate to form free glucose as the final step in gluconeogenesis.

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