Psammoma bodies are seen in -

Papillary thyroid carcinoma It is the most common type of thyroid cancer. Carcinoma cells have nuclei which contain finely dispersed chromatin, which imparts optically clear or empty appearance, giving rise to the ground glass or Orphan Annie eye nuclei. Invagination of cytoplasm may give rise to the appearance of intranuclear inclusions (pseudoinclusions) or intranuclear grooves the diagnosis of papillary carcinoma is based on these nuclear features. Psammoma bodies are present Lymphatic metastasis may be seen but the involvement of blood vessels is rare.