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Gynaecology & Obstetrics General e5941424

Which anti-epileptic is not contraindicated during pregnancy?

A
Ethosuxmide
B
Carbamazepine
C
Phenytoin
D
Valproate
High-Yield Explanation
Carbamazepine REF: The treatment of epilepsy Simon D. Shorvon - Page 279 "Carbamazepine is the antiepileptic of choice during pregnancy" The latest data from Jentink et al (BMJ 2010;341:c6581) are drawn from the EUROCAT Antiepileptic Study Database and show that carbamazapine was associated with a raised incidence of spina bifida but the absolute risk was small -- 2 per 1000 against a background rate at 1 per 1000.

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