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Biochemistry Miscellaneous (Structure & Function of Proteins) e57d168f

Role of Ubiquitin in cell -

A
Energy dependent protein folding
B
Energy independent protein folding
C
Energy dependent protein degradation
D
Energy independent protein degradation
High-Yield Explanation
Ans. is 'c' i.e., Energy dependent protein degradation o There are two major enzyme systems responsible for degradation of damaged or unneeded proteins1) Ubiquitin-proteosome proteolytic pathway# Defective protein is first covalently attached to ubiquitin. Covalent bond is formed between glycine (a- carboxyl group) of ubiquitin and lysine (amino group) of target protein.# Ubiquitinated protein is then degraded in proteosomes by ATP dependent (energy dependent) mechanism.2) Lysomes# Proteins are degraded by proteolytic enzymes which is energy independent (non-energy dependent).

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