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Pharmacology General e482ac72

Not true about thalidomide :

A
Causes phocomelia
B
Not tested in pregnant animals before introduction
C
Still has restricted clinical use
D
Has no antiangiogenesis action against tumour
High-Yield Explanation
Thalidomide was banned in 1960 because of its teratogenic effect of phocomelia (seal-like limbs). It has anxiolytic, adjuvant analgesic/antipyretic properties and has been found to counteract cancer-associated cachexia. Its mechanism of action is by suppressing TNF and or by modulating IL-2. Recently it has been reintroduced as an antineoplastic drug due to its anti-angiogenesis action.

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