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Medicine Disorders of pituitary gland e3cf8671

Level of which hormone is likely to increase after hypothalamic ablation?

A
Growth hormone
B
Prolactin
C
FSH
D
ACTH
High-Yield Explanation
Prolactin secretion from the pituitary is normally inhibited by hypothalamic inhibitory factors, one of which is dopamine. Histamine also inhibits prolactin secretion, whereas serotonin and thyrotropin releasing hormone (TRH) stimulate its release. Causes of Hyperprolactinemia Lesions obstructing the inhibitory influence from the hypothalamus (e.g. craniopharyngioma, sarcoidosis, surgical ablation) Increased stimulation (elevated TRH in primary hypothyroidism). Prolactin-secreting pituitary adenomas. Exogenous sex steroids, phenothiazines, ceain antidepressants, and antihypeensives may also cause hyperprolactinemia.

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