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Pharmacology General e2979616

Which one is not converted to an active metabolite?

A
Quinapril
B
Fosinopril
C
Benzopril
D
Lisinopril
High-Yield Explanation
Lisinopril: It is the lysine derivative of enalaprilat; does not require hydrolysis to become active ACE inhibitor.   KEY CONCEPT:- All ACE inhibitors are prodrugs except captopril and lisinopril. Other drugs like enalapril are converted to its active metabolite (enalaprilat) and thus are slow acting. Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 532

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