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Gynaecology & Obstetrics Infeility (Eggs'plantation!) e287f404

Clomiphene citrate, apa from ovulation induction, can be tried for which of the following disorders?

A
Oligospermia
B
Erectile dysfunction
C
Asherman's syndrome
D
Carcinoma endometrium
High-Yield Explanation
Clomiphene is thought to have effects on the hypothalamic axis which promotes gonadotropin release. Gonadotropin stimulates pituitary LH & FSH secretion which helps in testosterone production and hence in spermatogenesis. The drug is staed at a dose of 25mg daily dose to increase the FSH. Usually given for a period of 3 months, the spermatogenesis cycle length. This regime is an 'OFF-Label" use in practice since its not yet universally accepted. However, its a frequent therapy given prior to going in for more elaborate and expensive treatment by IVF.

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