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Medicine Hereditary Hyperbilirubinemia & Jaundice e23b1899

Raised unconjugated hyperbilirubinemia is seen in:

A
Gilbe's Syndrome
B
Dubin Johnson syndrome
C
Drug induced cholestasis
D
Hepatocellular necrosis
High-Yield Explanation
Gilbe's syndrome- mild unconjugated hyperbilirubinemia, normal values for standard hepatic biochemical tests and normal hepatic histology other than a modest increase of lipofuscin pigment in some patients. Serum bilirubin concentrations are most often < 3 mg/dL. Extra edge : Crigler-Najjar syndrome I is often lethal, although Crigler-Najjar syndrome II is compatible with life and often presents with extreme jaundice and neurologic defects secondary to kernicterus. Both DubinJohnson syndrome and Rotor syndrome cause conjugated hyperbilirubinemia

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