First to be blocked by muscle relaxants

First muscles to be blocked by muscle relaxants (both depolarizing and non-depolarizing type) are central muscles i.e., muscles of head and neck (face, jaw, pharynx, larynx), respiratory, abdominal muscles and muscles of trunk. After the central muscles, muscles of limbs (peripheral muscles) are blocked.muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to allete symptoms such as muscle spasms, Ref Robbins 9/e 456