Pharmacology General e14969c5

All are true about sulphonyl ureas except?

It blocks ATP sensitive K+ channels and increase insulin release

They have higher risk of causing hypoglycemia than meglitinides

They are used mainly in type 1 DM

Chlorpropamide can cause dilutional hyponatremia

High-Yield Explanation

Sulphonyl ureas are mainly used in Type 2 DM because Type 1 DM is characterized by autoimmune destruction of β - cells of pancreas and atleast 30% of β - cells should be present for sulphonyl ureas to be effective.

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All are true about sulphonyl ureas except?

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