Medicine General e0fedf2b Wide split S2 occurs in: A VSD (ventricular septal defect) B Mitral stenosis C ASD (Atrial septal defect) D c ansd a both High-Yield Explanation Answer is C >A (ASD > VSD) Wide physiological splitting may be seen in both VSI) and AS!) but it is more characteristic of ASD. ASD is the single best anterior of choice.