Pharmacology All India exam e0fd9112

Indomethacin reduce the diuretic action of furosemide by

Preventing prostaglandin mediated heamodynamic actions

Blockade of furosemide action in loop of henle

Enhancing water reabsorption in distal tubule

Increasing aldosterone secretion

High-Yield Explanation

NSAIDS inhibit specifically PGE2, PGI2 synthesis in renal tubules effecting the hemodynamic changes done by Prostaglandins for water, sodium reabsorption Ref: katzung 12th ed, Autocoids.

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