True regarding amyloidosis are, A/E ?

Ans. is None o It is also the most serious form of organ involvement. The size of kidney is characteristically normal or increased. The earliest pathological change seen in renal amyloidosis is mesangial expansion by amorphous hyaline material and thickning of the glomerular basment membrane. o Amyloid is primarily deposited in the glomeruli, but interstitial peritubular tissue, aeries and aerioles are also affected. With time there is capillary narrowing and distoion of glomerular tufts. o Eventually the glomerulus obliterated completely. Clinical manifestations Nephrotic range proteinuria (most common) o Fanconi syndrome Edema (due to albuminemia) o Nephrogenic diabetes insipidus Azotemia (when there is tubular involvement) o Renal tubular acidosis Urine may show RBC cast. o Hypeension (in 20-50%) Renal vein thrombosis