AGE-RAGE signaling axis is related to

AGE-RAGE signalling axis is related to chronic complications in diabetes.Advanced glycation end products (AGEs) are formed as a result of nonenzymatic reactions between intracellular glucose-derived dicarbonyl precursors (glyoxal, methylglyoxal, and 3-deoxyglucosone) with the amino groups of both intracellular and extracellular proteins. The natural rate of AGE formation is greatly accelerated in the presence of hyperglycemia. AGEs bind to a specific receptor (RAGE) that is expressed on inflammatory cells (macrophages and T cells), endothelium, and vascular smooth muscle.Robbins pathology 9e pg: 1115