A 14-year-old presented with recurrent episodes of epistaxis along with characteristic skin and mucous membrane lesions. The lesions were seen at dorsum of tongue, oral cavity, buccal mucosa, lips, palate and nasal mucosa. Lab findings revealed normal coagulation profile. Which of the following drugs has been recently approved for the above condition: -

This is a case of hereditary hemorrhagic telangiectasia. Normal coagulation profile rules out bleeding disorders. The image shows 1-4 mm, sharply demarcated red to purple macules, papules, or spider-like projections, each composed of a tightly woven mat of touous telangiectatic vessels. Autosomal dominant inheritance Presents as epistaxis in 80% of patients. May have pulmonary AVMs leading to strokes and embolic abscesses. Bevacizumab has been approved for this.