Which of the following SSRI is a prodrug?

Ans. is 'a' i.e., Fluoxetine Selective serotonin reuptake inhibitors (SSRI) 5-HT (serotonine) is the major player in depressive illness and serotonergic pathways are closely related to mood disorders especially depression. Thus, drugs affecting the 5-HT levels in the neural synapse and serotonergic pathways are effective in the treatment of depression. Therefore, the SSRIs have been shown to allete depression and are the most commonly used drugs in the therapy of depression. These drugs act by inhibiting reuptake of 5-HT. These drugs are now 1st choice for depression. Advantages over TCAs. 1.Little or no sedation, no weight gain. 2.No interference with psychomotor or cognitive function. 3.No anticholinergic side effects. 4.No postural hypotension (no action of a-adrenergic receptors). 5.No propensity to cause seizures or arrythmias.