All of the following statements are true related to histamine, except:

Histamine Stored as preformed molecules in mast cells and is therefore among the first mediators to be released during inflammation. Causes dilation of aerioles and increases the permeability of venules. Can cause contraction of some smooth muscles such as in lungs. H1 receptor antagonists that bind to and block the histamine receptors are used to inflammatory reactions (allergies).