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Physiology General df5a69d9

Which of the following feature(s) is/are suggestive of nehogrnic DI in comparison to central DI :

A
Desmopressin nasal spray restore urine output to normal level
B
Basal vasopressin level > 1 pg/ml
C
Normal posterior pituitary bright spot is not visible on MRI scan
D
Change in water loss during fluid deprivation test
High-Yield Explanation
Ans: b. Basal vasopressin level > 1 pg/mlFailure to Produce ADH: "Central" Diabetes Insipidus.The treatment for central diabetes insipidus is administration of a synthetic analog of ADH, desmopressin, which acts selectively on V2 receptors to increase water permeability in the late distal and collecting tubules.Desmopressin can be given by injection, as a nasal spray, or orally, and it rapidly restores urine output toward normal.The polyuria anil polydipsia of nephrogenic DI are not affected by treatment *ith standard doses of DDAVP.

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