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Pharmacology Cardiovascular system df34e86c

Angiotensin conveing enzyme inhibitors when used for a long time in patients with hypeension, cause:

A
Rightward shift in renal pressure-natriuresis curve
B
Reduction in glomerular filtration fraction
C
Significant increase in hea rate
D
No change in compliance of large aeries
High-Yield Explanation
Unlike the direct-acting smooth muscle vasodilators or adrenergic inhibitors, ACE inhibitors dilate the efferent as well as the afferent glomerular aerioles and thereby reduce glomerular hydrostatic pressure and renal filtration fraction, even though renal blood flow and glomerular filtration rate are preserved. Ref: KD Tripathi 8th ed.

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