NOT True about Gout

C. i.e. (Not found in woman after menopause) (2165 - H17th) (69 - Apley 8th) (714-CMDT 09)GOUT* Purine metabolic disease affecting middle aged to elderly men and post menopausal women*** Deposition of monosodium urate (MSU) crystals** in the joints and connective tissue tophi* Much commoner in Caucasian than in black African people* Late changes include cartilage degeneration, renal dysfunctions and uric acid urolithiasis* Precipitating factors - minor trauma, operation, intercurrent illness, unaccustomed exercise or alcohol* Commonest site are the metatarsophaangeal joint of the big toe**, the ankle and finger joints and olecranon bursae* Definitive diagnosis - characteristic negatively birefringent urate crystal in the synovial fluid*** Hyperuricemia is not diagnostic and is often seen in normal middle age men* Uric acid kidney stones are present in 5 - 10% of patients with gouty arthritis* Patients with gout are anecdotally thought to have an increased incidence of hypertension, renal disease (eg nephrosclerosis, interstitial nephritis pyelonephritis) DM, hypertriglyceridemia and atherosclerosis