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Pathology General de36dd09

True about membranous GN are following except -

A
Thickening of B.M
B
Deposition between endothelium and B.M.
C
Most common cause of nephrotic syndrome in adults
D
Seen in SLE, tumors, drugs
High-Yield Explanation
Membranous glomerulonephritis Membranous glomerulonephritis, also known as membranous nephropathy, is a slowly progressive disease of the kidney affecting mostly patients between ages of 30 and 50 years. Membranous glomerulonephritis is classified Primary (idiopathic) - 85% Secondary  - 15% Drugs → Penicillamine, captopril, gold, NSAIDS Malignant tumors → Lung, colon, melanoma Autoimmune conditions → SLE, thyroiditis Infections → HBC, HCV, syphilis, schistosomiasis, malaria Membranous glomerulonephritis is characterized by - Diffuse thickening of the glomerular capillary wall. Accumulation of electron - dense, immunoglobulin containing deposits along subepithelial side (between epithelium and GBM). Membranous glomerulonephritis is the most common cause of nephrotic syndrome in adults.

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