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The therapeutic effect of sulfasalazine in ulcerative colitis is exerted by :

A

Inhibitory action of the unabsorbed drug on the abnormal colonic flora

B

Breakdown of the drug in colon to release 5–amino-salicylic acid which suppresses inflammation locally

C

Release of sulfapyridine having antibacterial property

D

Systemic immunomodulatory action of the drug

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