Which of the following actions is ascribed to delta type of opioid receptors -

Ans. is 'a' i.e., Supraspinal analgesia (Mu) o Analgesia (spinal + supraspinal) o Respiratory depression o Euphoria Reduced G1 motility Sedation Miosis Physical dependence Increased feeding 1c (Kappa) Analgesia (spinal + Supraspinal) Respiratory depression (lower ceiling) Dysphoria o Reduced GI motility Sedation Diuresis Increased feeding Psychomimetic effects S (Delta) Analgesia (spinal + Supraspinal) Modulation of GH & DA release Increased feeding a (sigma) receptor (nonpioid receptor) mediates naloxone insensitive effects of pentazocine, e.g., dysphoria, psychomimetic action, tachycardia and mydriasis. Remember o Psychomimetic effects (hallucinations, anixety and night mares) of agonist-antagonists (nalbuphine, dezocine) are due to K receptors. o Ceain endogenous peptides (endrophins, enkephalins and dynorphins) act on these opioid receptors and produce analgesia. o A new endogenous peptide nociception has been isolated which acts on orphanin like receptors (ORLs) or nociception/orphanin fQ (N/oFQ) receptors. o Endorphins have major action on receptors. o Enkephalins have major action on 6 receptors. o Dynorphins have major action on x receptors.