Nude mouse is used in genetics because of the following properties -a) Absence of thymusb) Xenograft can be sustained for weeksc) Severe combined immunodeficiency mice is same as nude miced) they can generate mature T lymphocytes

The genetic basis of nude mouse mutation is a disruption of the FOXN1 gene. Characteristics of nude mouse mutation are:- AR mutation of a nu locus on chromosome 11 Thymic aplasia T-cell deficient Normal B-cell function. Phenotypically hairless. Accepts xenograft and allograft transplantation Insusceptible to graft-versus-host disease No generation of cytotoxic effector cells SCID mutation occurs on chromosome 16. SCID mouse has a thymus, lymph nodes and splenic follicles virtually devoid of lymphocytes.