Social & Preventive Medicine General dce8cce5 What is the recommended drug for treatment of leptospirosis? A Penicillin B Tetracycline C Azithromycin D Erythromycin High-Yield Explanation Penicillin is the drug of choice for treatment of leptospirosis. Tetracycline or doxycycline may also be used. Ref: Park 21st edition, page 267.