Drug used in irritable bowel syndrome with constipation is:

Ans. (A) Lubiprostone(Ref: Katzung 11/e p1080)Lubiprostone acts by stimulating Cl- channel opening in the intestine, increasing liquid secretion in gut and decreasing transit time, therefore used for chronic constipation. It has also been approved for constipation dominant irritable bowel syndrome in women.