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Pharmacology Cytotoxic Anticancer Drugs dc48db29

All of the following statements about methotrexate are true EXCEPT:

A
It is cell cycle specific and kills cells in the S phase
B
Its toxicity primarily affects bone marrow and epithelial structures
C
Folic acid reverses its toxic effects
D
It is the drug of choice for choriocarcinoma
High-Yield Explanation
Folinic acid (leucovorin) is used to reverse the adverse effect of methotrexate. Folic acid is ineffective. All other statements are true

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