Pharmacology Cytotoxic Anticancer Drugs dc48db29 All of the following statements about methotrexate are true EXCEPT: A It is cell cycle specific and kills cells in the S phase B Its toxicity primarily affects bone marrow and epithelial structures C Folic acid reverses its toxic effects D It is the drug of choice for choriocarcinoma High-Yield Explanation Folinic acid (leucovorin) is used to reverse the adverse effect of methotrexate. Folic acid is ineffective. All other statements are true