Which of the following statements about Diabetes Insipidus is true -
High-Yield Explanation
In diabetes insipidus, urine is not maximally concentrated (osmolality below 600 mOsm/kg) in the presence of increased plasma osmolality (greater than 300 mOsm/kg). The diagnosis can be confirmed or refuted by random simultaeous samples of blood and urine, but more often a dynamic test like water deprivation test is required. Reference : page 794 Davidson's Principles and practice of Medicine 22nd edition