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Pharmacology Other topics and Adverse effects dbe77d7d

Which of the following prokinetic drugs produces extrapyramidal side effects?

A
Metoclopramide
B
Cisapride
C
Domperidone
D
All of the above
High-Yield Explanation
(Ref: KDT 6/e p643, 644) Metoclopramide and domperidone act by blocking D2 receptors. Metoclopramide can cross BBB whereas domperidone cannot. Therefore, metoclopramide can produce extra-pyramidal adverse effects while domperidone is devoid of it. Cisapride acts as 5HT4 agonist. It can cause torsades de pointes.

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