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Anatomy General anatomy dbd8ee6e

Which is wrong about Crigler-Najjar syndrome Type - 1

A
Very high level of unconjugated bilirubin occurs in Neonatal period
B
Kernicterus is usual
C
It responds well to phenobarbitone
D
Hepatic histology is normal
High-Yield Explanation
Criggler Najjar syndrome Feature Type 1 Type 2 Total serum bilirubin (mg/dl) 18-45(usually >20)) 6-25(usually 20) Routine liver tests normal Normal Response to phenobarbitone None Decreases bilirubin by >25% Kernicterus Usual Rare Hepatic histology Normal Normal Bile characteristics. Color Pale or colorless pigmented Bilirubin fractions >90% unconjugated Largest fraction (mean:57%) monoconjugates Bilirubin UDP-glucuronosyl transferase activity Typically absent, traces in some patients Markedly reduced :0-10% of normal Inheritance Recessive Predominantly recessive (AR>AD)

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