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Pharmacology Antiplatelets and Fibrinolytics dbb05716

Half life of alteplase is ?

A
5mins
B
30mins
C
1 hour
D
2 hour
High-Yield Explanation
Ans. is 'a' i.e., 5 mins o Alteplase has a very short half-life (about 5 minutes) and, therefore, is administered as a total dose equal to 0.9mg kg.o Ten percent of the total dose injected intravenously as a bolus and the remaining drug is administered over 60 minutes.

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