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Pediatrics Genetic and genetic disorders db6afc60

Causes of female pseudohermaphrodism is ____________

A
17-alpha hydroxylase deficiency
B
21-alpha hydroxylase deficiency
C
Mixed gonadal dysgenesis
D
All of the above
High-Yield Explanation
21 alpha hydroxylase dficiecy is characterised by deficiency of glucocoicoids and mineralocoritcoids with elevated androgen level. Excess androgen production during the critical period of fetal development leads to masculinization of female. female pseudohermaphroditism is a condition in which the gonadal sex is female, but the external genitalia are masculinized. Reference: Ghai textbook of pediatrics 8th edition pg 539

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