Psychiatry Schizophrenia Spectrum and Other Psychotic Disorders db522b44 Schizophrenia is a common presentation is which genetic disease? A Down's syndrome B DiGeorge syndrome C Klinefelter's syndrome D Neurofibromatosis High-Yield Explanation DiGeorge syndrome (22q11.2 deletion, velocardiofacial syndrome):30% have schizophrenia when reaches adulthood.