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Biochemistry Metabolism of nucleic acids db2823c5

Immediate precursor of creatine

A
Carbamoyl phosphate
B
Arginosuccinate
C
Guanidoacetate
D
Citrulline
High-Yield Explanation
Creatine constitutes about 0.5% of total muscle weight.It is synthesized from 3 aminoacids, glycine,arginine and methionine. STEP 1 :In the first reaction the amidino group of arginine is transferred to glycine to form guanidoacetic acid,catalysed by amido transferase. STEP 2 :Guanidoacetic acid is methylated by S-adenosyl methionine (SAM) bt methyl transferase to form creatine. STEP 3 :Creatine is phosphorlated to creatine phosphate.The reaction needs hydrolysis of ATP. STEP 4 :The creatine phophate may be conveed to its anhydride, creatinine.It is a non-enzymatic spontaneous reaction. REF :DM VASUDEVAN TEXTBOOK ;7th EDITION ; Page no :211

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