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Pediatrics Childhood Tumors db16cc01

ADAMTS-13 is a metalloproteinase. It is produced by the:

A
Alfa cells of the pancreas
B
Oligodendrocyte in the brain
C
Stellate cells in the liver
D
Tubular epithelial cells of the kidney
High-Yield Explanation
Ans. C. Stellate cells in the liverADAMTS-13 is a metalloproteinase which is produced by the stellate cells of the liver. It cleaves von Willebrand factor. Therefore, when ADAMTS-13 deficiency occurs, large multimer of VWF attach to platelets and cause microcirculatory failure.

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