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Pharmacology General dade6524

Which of the following drug inhibits the enzyme of initial step of cholesterol synthesis ?

A
Lovastatin
B
Gemfiberozil
C
Probucol
D
Cholestyramine
High-Yield Explanation
Ans. is 'a' i.e., Lovastatin o Statins (Lovastatin) competitively inhibit the conversion of HMG-CoA to mevalonate (rate limiting step in cholesterol synthesis) by inhibiting the enzyme HMG-CoA reductase.

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