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Pharmacology General dac66fe5

All of the statements about exenatide are true except:

A
It is a GLP–1 analogue
B
It can be used for treatment of Type 1 diabetes mellitus
C
It is given subcutaneously
D
It decreases glucagon
High-Yield Explanation
Exenatide (Exendin 4) is a GLP-1 receptor agonist that is more resistant to DPP-4 action and cleared by the kidney. When this drug is given to patients with type 2 diabetes by subcutaneous injection twice daily, it lowers blood glucose and HbA1c levels. It is not indicated in type 1 diabetes. Exenatide appears to have the same effects as GLP-1 on glucagon suppression and gastric emptying. Only drugs approved for treatment of type 1 diabetes are insulin and pramlintide.

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